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Doi No: 10.5578/mb.67169

İlk Altı Ayda Maternal Kızamık, Kızamıkçık, Kabakulak ve Suçiçeği Antikorlarının Durumu

Prevalence of Maternal Measles, Rubella, Mumps and Varicella Antibodies in the First Six Months of Life

Esra DEVECİOĞLU1, Gülbin GÖKÇAY2, Perran BORAN3, Tijen EREN4, Gonca YILMAZ5, Selim BADUR6


1 İstanbul Üniversitesi İstanbul Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, İstanbul.

1 Istanbul University Faculty of Istanbul Medicine, Department of Pediatrics, Istanbul, Turkey.

2 İstanbul Üniversitesi Çocuk Sağlığı Enstitüsü, Sosyal Pediatri Bilim Dalı, İstanbul.

2 Istanbul University Institute of Child Health, Social Pediatrics Unit, Istanbul, Turkey.

3 Marmara Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Sosyal Pediatri Bilim Dalı, İstanbul.

3 Marmara University Faculty of Medicine, Department of Pediatrics, Division of Social Pediatrics, Istanbul, Turkey.

4 Koç Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, İstanbul.

4 Koç University Faculty of Medicine, Department of Pediatrics, Istanbul, Turkey.

5 Dr. Sami Ulus Kadın Doğum, Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Sosyal Pediatri Bilim Dalı, Ankara.

5 Dr. Sami Ulus Children and Maternity Training Hospital, Social Pediatrics Unit, Ankara, Turkey.

6 İstanbul Üniversitesi İstanbul Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Viroloji ve Temel İmmünoloji Bilim Dalı, İstanbul.

6 Istanbul University Faculty of Medicine, Department of Medical Microbiology, Division of Virology and Basic Immunology, Istanbul, Turkey.

*Bu çalışma, İstanbul Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi tarafından 35513 no'lu proje ile destelenmiştir.

ABSTRACT

The protection of infants against infections during the first few months of life is provided mainly by maternal antibodies. The presence of maternal antibodies can decrease vaccine efficacy. The waning time of maternal antibodies shows variations therefore seroepidemiological studies are important for the development of vaccination schedules. Some recent studies showed that the maternal measles antibodies may disappear around 3 months of age especially in infants born from mothers who were vaccinated. There are few cross-sectional studies from Turkey evaluating the maternal antibody levels of infants against measles in recent years. The aim of this prospective, multicentre study is to evaluate the seropositivity of measles, rubella, mumps, and varicella in mothers and their infants at 1 and 6 months after birth. The study was carried out at the Social Pediatrics Units of two university hospitals, a private hospital and a state hospital. The exclusion criteria were known impaired immune system or immune deficiency disorder in mother or child, preterm delivery (< 37 gestational week), administration of immunoglobulins or any blood products before admission or during the follow-up period, and history of vaccination or exposure to one of these diseases during the study period. The final analysis encompassed 209 mother-infant pairs. Blood samples were collected 1 month after birth from mothers and 1 and 6 months after birth from their babies. Antibody levels were determined by ELISA (Enzyme-Linked ImmunoSorbent Assay) method. Information on the socio-economic and demographic characteristics of the families were collected by a face-to-face questionnaire. Seropositivity was found as 95.7%, 92.8%, 92.8% and 96.7% for measles, mumps, rubella and varicella (MMRV) respectively. Majority of infants lost maternal antibodies at 6 months of age. Of all 6 month-old infants 25% were seropositive for measles,14.6% for mumps, 23.2% for rubella and 17.1% for varicella. The proportion of seropositive infants born from seropositive mothers was higher than those born from seronegative mothers for all four diseases. This difference was statistically significant only at 1 month of age (p= 0.001). Our study showed that maternal antibodies against MMRV decreased rapidly by 6 months of age therefore necessary measures should be taken to close this gap between the loss of maternal protection and the vaccination of infants for MMRV. As the epidemiology of the diseases changes in time, it is important to carry out such studies with large series in different countries and settings. Important results were determined in our study within this respect.

Keywords: Maternal antibodies; measles; mumps; rubella; varicella.

Geliş Tarihi (Received): 16.01.2018 - Kabul Ediliş Tarihi (Accepted): 30.06.2018

İletişim (Correspondence):

Dr. Esra Devecioğlu Karapınar,

İstanbul Üniversitesi İstanbul Tıp Fakültesi,

Çocuk Sağlığı ve Hastalıkları Anabilim Dalı,

Millet Caddesi, Çapa Fatih, İstanbul, Türkiye.

Tel (Phone): +90 212 414 2000,

E-posta (E-mail): esradevecioglu@gmail.com

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